Evaluate why eliminating malaria is so much harder than eliminating smallpox, even though effective vaccines exist for smallpox.

• Asmallpox had a simpler genome, making it easier to target with drugs
• Bmalaria involves a complex life cycle in two hosts (human and mosquito), a rapidly evolving parasite, and a vector that is difficult to eradicate; in contrast smallpox only infected humans and had a stable, immunogenic antigen that was the same worldwide
• Cthere is no difference - malaria could be eliminated just as easily but funding is not available
• Dsmallpox was eliminated by antibiotics, not vaccines, and no antibiotics exist for malaria

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